Discover 50 ways to treat acne using natural remedies. Acne is a skin disease that involves the oil glands found at the base of hair follicles. These glands come to life during puberty due to both male and female hormones produced at that time. Because of these hormones, this is the time acne usually occurs. Acne occurs when the oil glands at the base of hair follicles get blocked and oil accumulates under the skin.